William J. Karpus
Credentials: PhD
Position title: Professor, Dean of the Graduate School
Email: william.karpus@wisc.edu
Phone: (608) 263-1353
Address:
217 Bascom Hall
500 Lincoln Dr.
Madison, WI 53706
- Office
- 217 Bascom Hall
Research Interests
My research interest has been the role of chemokines in experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). We have employed the model system to understand leukocyte migration in demyelinating disease pathogenesis. Key chemokines and receptors were identified that played a role in the regulation of leukocyte migration and function using a variety of approaches including neutralizing antibody treatment and mice deficient for select chemokine ligands or receptors. These studies identified significant roles for a subset of chemokines and chemokine receptors in EAE pathogenesis and point to these factors as potential therapeutic targets for MS. Additionally, we demonstrated a role for Delta Like Ligand-mediated Notch signaling in the regulation of chemokine receptor cell surface expression that controls T cell migration to the central nervous system (CNS). I am currently not accepting new students or postdoctoral fellows.