William J. Karpus

PhD

Professor, Dean of the Graduate School

william.karpus@wisc.edu

608-262-2433

217 Bascom Hall
500 Lincoln Dr.
Madison, WI 53706

Office
217 Bascom Hall

Research Interests

I have been studying the role of chemokines in experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) for 21 years and have been using rat and mouse models of MS to understand demyelinating disease pathogenesis for the past 29 years. We have identified key chemokines and receptors in the regulation of T cell and macrophage migration and function using a variety of approaches including neutralizing antibody treatment and mice deficient for select chemokine ligands or receptors. These studies have identified significant roles for a subset of chemokines and chemokine receptors in EAE pathogenesis and point to these factors as potential therapeutic targets for MS. More recently, we have observed a role for Delta Like Ligand-mediated Notch signaling in the regulation of chemokine receptor cell surface expression in the control of T cell migration to the central nervous system (CNS). Additionally, we have considerable experience investigating mechanisms of immunologic tolerance in CNS demyelinating diseases as an approach for antigen-specific therapy. The current project will determine mechanisms of chemokine regulation that control lymphocyte entry into the brain and identify new drug targets for relapsing MS therapy.

Selected Publications
  • Karpus WJ. Cytokines and Chemokines in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. J Immunol. 2020 Jan 15;204(2):316-326. doi: 10.4049/jimmunol.1900914. Review. PubMed PMID: 31907274.
  • Hsu M, Rayasam A, Kijak JA, Choi YH, Harding JS, Marcus SA, Karpus WJ, Sandor M, Fabry Z. Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells. Nat Commun. 2019 Jan 16;10(1):229. doi: 10.1038/s41467-018-08163-0. PubMed PMID: 30651548; PubMed Central PMCID: PMC6335416.
  • Karpus WJ. Inflammatory macrophage migration in experimental autoimmune encephalomyelitis. Methods Mol Biol. 2013;1013:161-9. doi: 10.1007/978-1-62703-426-5_10. PubMed PMID: 23625498.